Wrinkles are due to sun damage and genetic factors and are just part of the normal aging process. So what can you do if you want to do something? All attempts at treating wrinkles aim at increasing the amount of connective tissue in the skin, whether that connective tissue is collagen, elastin or the surrounding ground substance (mostly known as hyaluronic acid). That connective tissue can be injected in the form of fillers, an example of which is Juvederm or Restylane, or, your skin can be stimulated to produce its own connective tissue. Retin-A, chemical peels and CO2 lasers all work by causing a lesser or greater degree of skin trauma (in a medically controlled way), and then as your skin heals it produces the needed connective tissue. The cornerstone of therapy is topical Retin-A also called tretinoin and retinoic acid. Retin-A is the acid derivative of Vitamin A (an alcohol) and is a prescription product. Other topical products are the hydroxy acids but overall these seem to work less well but may be better tolerated by sensitive skin.